The most recent technology of Vertus® automated shake and hearth platforms from Copley Scientific make it simple and intuitive to combine automation into a variety of drug product testing workflows to spice up productiveness, drive down take a look at variability, and simplify coaching. The Vertus® III+ is the corporate’s new flagship, absolutely automated benchtop system for pressurised metered dose inhaler (MDI), nasal spray and nasal aerosol testing. Comprehensively up to date to fulfill testing necessities for an excellent wider vary of gadget varieties, it incorporates a larger array of interchangeable take a look at plates and, built-in shot weight measurement. The DecaVertus® III is a complementary, excessive throughput answer for firing-to-waste, with the capability to concurrently discharge 10 units below equivalent situations to these utilized by the Vertus III+. Each function a brand new exhaust system that eases the dealing with of extremely flammable propellants. Collectively they current a compelling, extremely efficient answer for product testing.
The present regulatory and medical panorama has resulted in a surge of exercise in MDI reformulation and nasal drug product improvement; the Vertus platform might help considerably cut back the related burden of routine evaluation. Automated shake and hearth methods get rid of any requirement for handbook gadget actuation, simulating gadget dealing with by the affected person through parameters similar to shaking motion, time between doses, and actuation drive profile. By life testing for MDIs, which requires the firing of tons of of doses to waste, and regulatory steering that recommends a ‘mechanical technique of actuating the pump meeting be employed’ for spraysi are notable drivers for adoption.
The brand new Vertus methods are compliant with each pharmacopoeial specs and 21 CFR Half 11. Vertus and DecaVertus share an arc-like shaking movement according to typical analyst approach, enabling gadget actuation strategies developed on the Vertus to be transferred on to, and rigorously replicated on, the DecaVertus for firing-to-waste. Each shaking angle and firing drive ranges have been elevated relative to earlier fashions for larger flexibility with respect to check configuration.
Different key options of the brand new Vertus III+ embody:
- Built-in shot weight measurement for fast and environment friendly Uniformity of Delivered Mass testing for nasal answer merchandise, in step with compendial specs.
- A re-engineered exhaust port for easy connection to airflow extraction, making it simpler to deal with extremely potent medication and extra flammable propellants similar to HFA152a, a low world warming candidate for MDI reformulation.
- A big, adjustable display and intuitive person interface permitting simple interplay with minimal coaching.
- A brand new built-in priming and waste module for streamlined, automated testing, notably throughout all the contents, with minimal handbook enter.
- An intensive vary of interchangeable interface plates for take a look at equipment similar to a Spray Pressure Tester, Skinny Layer Chromatography plates (for spray sample), Alberta Idealised Throat and Alberta Idealised Nasal Inlet, for the great testing of each innovator and generic merchandise.
Discover out extra in regards to the subsequent technology of the Vertus household and the way they might remodel your testing apply.
Picture Credit score: Copley Scientific
About Copley Scientific
Copley Scientific is broadly recognised because the world’s main producer and provider of inhaled product testing tools and is a significant supplier of testing methods for different pharmaceutical dosage types. The corporate additionally provides tools for detergent testing.
Copley’s pharmaceutical product vary contains testing tools for all sorts of orally inhaled and nasal drug merchandise – metered-dose inhalers, dry powder inhalers, nebulisers and nasal merchandise – with a selected give attention to options for delivered dose uniformity and aerodynamic particle measurement distribution measurement. It additionally contains testers for tablets (dissolution, disintegration, friability and hardness) capsules, powders, suppositories, semisolids and transdermals.
Used from R&D via to QC, this intensive vary of kit is supported by a full validation and aftersales service. Copley works in partnership with specialist distributors, extending localised help internationally. This community offers knowledgeable assist and coaching to each buyer, straight enhancing the appliance of all Copley merchandise. www.copleyscientific.co
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