Ultima publicizes UG 100™ and divulges disruptive value and accuracy profile to allow the period of the $100 genome and past

Ultima Genomics, Inc., a developer of a revolutionary new ultra-high throughput sequencing structure, introduced the total industrial availability of the UG 100TM sequencer at present. The UG 100^TM system, Ultima’s first industrial product, leverages Ultima’s distinctive sequencing structure that includes an open silicon wafer substrate to switch the standard circulate cells and allow the $100 genome and past.

Our purpose when designing our sequencing structure and the UG 100^TM was to supply a know-how platform that allows a scalable roadmap past the $100 genome, ultra-high-output with out the restrictions of batching, and excessive accuracy in purposes for which it’s most wanted, … We’re excited to be launching the UG 100^TM and serving to the genomics group usher within the period of the $100 genome and past.

Gilad Almogy, founder and CEO of Ultima Genomics

The UG 100^TM, now accessible for buy, options Ultima’s proprietary wafer-based sequencing substrate with versatile, non-kit-based sequencing reagent cartridges and a novel sequencing chemistry. Not like extra conventional kit-based approaches, this distinctive structure permits built-in robotics, enabling full 24/7 run automation for improved flexibility with restricted person touchpoints. The UG 100^TM system additionally leverages latest developments in machine studying to enhance base calling and variant calling algorithms for improved accuracy and efficiency.

Choose key options of the UG 100 system embody:

• Low-cost reagents. One wafer and reagent configuration for $2,000 delivers 6-8 B reads and an anticipated common learn size of 300 base pairs or an output of as much as 2.4 Tb per wafer. This scalable configuration permits the $100 genome at an industry-leading value of $1.00 per GB or $0.30 per million reads.
• Flexibility and automation. Twin wafer sequencing run output of as much as 4.8 Tb at a run time of 14 hours, or lower than 12 hours for shorter learn purposes, and 6-8 B reads per wafer reduces the necessity for advanced batching whereas sustaining industry-leading value per Gb throughout a variety of pattern quantity. On-tool robotics and automatic run kick-off for full 24/7 operation and weekend sequencing operations with the usual 5-day work week.
• Medical high quality genomes. Distinctive flow-based chemistry and speedy developments in AI-based base and variant calling allow accuracy on par with different platforms with SNV F1 of 99.8 % and INDEL F1 of 99.4 %. The up to date GIAB reference knowledge set is obtainable on Ultima’s web site.
• Excessive accuracy for uncommon occasion purposes. Business-leading SNV accuracy profile and excessive accuracy know-how with ppmSEQ^TM.
• Excessive manufacturing instrument. Able to delivering 20 wafers per week and as much as 20,000 genomes per 12 months. For shorter learn purposes, the UG 100^TM delivers 28 wafers per week.

Introducing ppmSeq^TM – Q60 uncooked learn accuracy for base substitutions

Right now, the Firm can also be introducing ppmSeq^TM, a disruptive new mode for excessive uncooked learn accuracy in calling single nucleotide variants (SNVs). ppmSeq^TM is a brand new proprietary function enabled by Ultima’s distinctive method that dramatically improves the uncooked learn accuracy of calling SNVs by eradicating pattern errors launched upstream of the sequencing workflow. Utilizing this function, customers of Ultima’s sequencing system can obtain uncooked error charges for SNVs as little as 1 in one million or Q60 ranges of accuracy. Importantly, this function is native to Ultima’s sequencer and doesn’t require further prices, additional reagents, or workflow modifications.

With the launch of the UG 100^TM system, Ultima seems to allow the following wave of biology powered by low-cost sequencing knowledge era. The UG 100^TM system is at the moment accessible to order.