Hyaluronic acid injections stimulate long-lasting collagen renewal in aged pores and skin

Persistent publicity of human pores and skin to ultraviolet mild causes untimely ageing, or photoaging. Because the pores and skin undergoes photoaging, sort I collagen bundles, that are discovered within the dermis beneath the highest layer of the pores and skin and supply energy and assist to pores and skin, develop into fragmented. This results in wrinkles, fragility and lack of assist and elasticity. 

One of the best ways to stop injury to sort I collagen by daylight is to put on sunscreen persistently, every day if potential and significantly when spending time outside.”

Frank Wang, MD, the William B. Taylor Endowed Professor of Medical Dermatology at U-M Medical Faculty

Consultants noticed in a brand new research that injection of the most well-liked sort of dermal filler, cross-linked hyaluronic acid, into photoaged pores and skin may reverse the dermal adjustments related to photoaging. 

These fillers are usually injected into the pores and skin to scale back strains and wrinkles. They’re thought to offer scientific enchancment by including quantity to the pores and skin, however researchers have discovered that cross-linked hyaluronic acid additionally stimulates manufacturing of latest sort I collagen within the dermis. 

The filler does so quickly, stimulating collagen manufacturing inside a number of weeks of injection, and is long-lasting, selling the buildup of extra collagen over the course of a yr. 

These findings point out how the filler improves the looks of pores and skin within the short-term -; a mix of space-filling and collagen. Moreover, since newly fashioned dermal collagen lasts a few years, the findings additionally present perception into how the filler can promote long-term scientific enchancment, months or perhaps a yr after injection. 

“A single injection of cross-linked hyaluronic acid dermal filler can result in speedy and long-lasting enchancment of pores and skin by stimulating collagen deposition, and moreover, repeat injections could add extra collagen, ultimately lowering the necessity for re-treatment,” Wang stated. 

Further authors embody Thy Thy Do, Noah Smith, Jeffrey S. Orringer, Sewon Kang, John J. Voorhees, and Gary J. Fisher, the entire U-M Division of Dermatology.