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Examine reveals novel mind restoration mechanism after traumatic mind damage

A workforce of Medical College of South Carolina researchers, led by Onder Albayram, Ph.D., reviews in PNAS Nexus that they’ve found a novel protecting response by which the mind naturally repairs itself after traumatic mind damage. Findings might result in drug remedies that enhance the mind’s skill to get better after concussions and stop long-term mind illness.

“Mind restoration mechanisms are very, very highly effective,” stated Albayram. “We do not all the time should develop new remedy approaches. We are able to additionally simply give the mind an opportunity to heal itself correctly.”

Repetitive delicate traumatic mind damage, or repeated concussions, are frequent, particularly amongst athletes in high-contact sports activities or navy personnel concerned in fight. The long-term well being penalties of a concussion vary from delicate to extreme.

For some individuals, repeated blows to the top can set off a domino impact of secondary mind illness. They’ll develop power traumatic encephalopathy, a progressive kind of dementia with no identified treatment. In reality, mind accidents are the No. 1 environmental threat issue for neurodegenerative mind illnesses, comparable to Alzheimer’s illness or different dementias, stated Albayram.

That is the $1 million query: ‘Why do some athletes stay healthily into retirement, whereas others develop mind illness?’ We imagine it’s as a result of the restoration mechanisms within the mind will not be functioning effectively for some individuals.”


Onder Albayram, Ph.D., Medical College of South Carolina

After concussions, broken mind tissue builds up within the a part of the mobile compartment known as the mitochondria, he defined. This accumulation of broken tissue prevents the mitochondria from functioning effectively, main the mind cell to die. To restore itself, the mind can vacuum up the broken mitochondria in a course of known as mitophagy.

The protein p17 has been proven to play a small however distinctive position in mitophagy in different elements of the physique. Triggered by stress, the p17 protein transports essential enzymes to the cell, flags the broken tissue and initiates the therapeutic means of mitophagy. Albayram and his workforce needed to seek out out if p17 performed an analogous protecting operate within the mind. 

That is the primary research to indicate that the protein p17 does certainly play a vital position in defending the mind after repeated concussions. When researchers eliminated p17 within the mind cells of mice, they developed secondary illness after damage.

Albayram and his workforce then examined a therapeutic method for secondary mind illness. They created an analog drug that artificially triggered the restorative means of mitophagy in mice. Administering this drug to mice healed most of their mind illness.

To check their findings clinically, Albayram and his workforce examined postmortem human brains with and with out long-term mind illness from concussions. Albayram was shocked to seek out that protein p17 ranges have been notably decrease within the brains with illness. This end result confirms what the workforce found in preclinical fashions – that protein p17 performs a small however mighty position in how the mind protects itself from illness.

Protein p17 may very well be a goal for future remedies that defend the mind after concussions and stop long-term well being penalties.

As a result of researchers have been in a position to set off this restoration course of in a preclinical mannequin, a future aim is to develop related drug remedies for people. But, past simply traumatic mind damage, these findings might inform how we deal with mind illness broadly.

Albayram encourages mind scientists to not reinvent the wheel. Simply as vaccines increase the pure protecting properties of the physique to battle viruses, we are able to enhance the restoration properties of the mind to battle illness.

“We may help the mind to treatment itself,” stated Albayram.

Supply:

Journal reference:

Karakaya, E., et al. (2024). p17/C18-ceramide–mediated mitophagy is an endogenous neuroprotective response in preclinical and scientific mind damage. PNAS Nexus. doi.org/10.1093/pnasnexus/pgae018.


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Hector Antonio Guzman German

Graduado de Doctor en medicina en la universidad Autónoma de Santo Domingo en el año 2004. Luego emigró a la República Federal de Alemania, dónde se ha formado en medicina interna, cardiologia, Emergenciologia, medicina de buceo y cuidados intensivos.

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